Investigator

GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.

The Respiratory & Immunology Research Unit (RIRU) at GSK comprises multidisciplinary biology teams that utilize deep scientific knowledge and technical capabilities to identify and validate novel therapeutic targets and undertake drug discovery efforts from early stage through to phase 1 clinical trials.

We are seeking to hire a highly motivated biologist to fill an Investigator position in the Respiratory & Immunology Biology Unit (RIBU) within RIRU at GSK R&D in Upper Providence, PA. The successful candidate will be part of a multidisciplinary team to establish and characterize cellular models derived from human induced pluripotent stem cells (iPSCs), and to perform genetic perturbations (KD, KO, KI, overexpression) in iPSC-derived cells for drug discovery applications. The scientist will have the opportunity to work on targets and pathways relevant to a variety of human diseases and therapeutic areas including neuroscience, liver, renal, and metabolic diseases.

Job functions:

• Function as a technical expert in iPSC culturing, establishing and optimizing iPSC differentiation into cell types.
• Perform QC assays for characterization of iPSC-derived cellular models including immunocytochemistry, FACS analysis, and RT-qPCR using a variety of laboratory instruments and computer softwares.
• Conduct experiments to achieve high efficiency genetic manipulation (KD, KO, overexpression) in iPSC-derived cells.
• Collaborate with internal colleagues and external CROs to establish/transfer procedures for iPSC culturing and differentiation.
• Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies
• Comply with all standards and practices of data integrity, ethics, and safety
• Model GSK's values of patient-focus, respect, transparency, and integrity
• Communicate processes and study results with project teams and line leaders
• Work effectively with internal matrix partners and contribute to external study planning and oversight (i.e. CRO).
• Present scientific ideas and findings, both verbally and in written forms to internal teams.
• Maintain accurate and detailed electronic laboratory records in alignment with data integrity standards and ensure compliance with all relevant SOPs and Risk Assessments and safety guidelines.
• Foster a culture of innovation, collaboration, inclusion, and continuous learning within the research teams and across the organization.

Why You?

Basic qualifications:

• MSc in biological sciences
• Five or more years of relevant experience in molecular biology and/or cell biology.
• Three or more years of experience in the following areas:
  • iPSC culturing and differentiation
  • Genetic manipulation techniques including siRNA and gene overexpression
  • Cell-based assays (e.g. ELISA, reporter gene assay, etc.)
  • Executing experiments independently and work collaboratively with colleagues
  • Analyzing, summarizing, interpreting, presenting experimental data, and maintaining accurate/legible records.

Preferred qualifications (one or more of the following):

• PhD in biological sciences with two or more years of relevant experience in molecular biology, cell biology, or neuroscience
• Experience using viral delivery vectors
• Experience with FACS cell analysis
• Experience with high content imaging and data analysis
• Experience with iPSC differentiation into a neuronal cell type
• Strong documentation, communication, and teamworking skills
• Experience in CRISPR cell engineering
• Willing to work flexible hours
• Ability to work independently as well as collaboratively in a team-oriented environment.

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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