Associate Director, Computational Biology and Data Science, Translational Medicine

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Translational Medicine Computational Biology & Data Science is seeking an independent and self-motivated expert in machine learning and bioinformatics to support a broad range of data-driven projects for immunology/autoimmune and oncology therapeutic areas. The successful candidate will provide collaborative analytical and machine learning/AI support to Discovery and Translational projects, including target identification, biomarker discovery, and the interpretation of high-dimensional data sets to inform translational and therapeutic decisions.

Essential Functions of the Job (Key responsibilities)

• Implement vision for AI/ML to support Discovery and Translational programs and projects.
• Provide AI/ML analytical support for translational data in preclinical projects and clinical programs.
• Analyze and interpret internal and external NGS (DNA-seq/RNA-seq/scRNA/CITE-seq/spatial profiling) and clinicogenomics data sets.
• Identify and evaluate pharmacodynamic and predictive biomarkers for translational programs.
• Provide technical expertise and biological interpretation of analysis results within a highly collaborative environment.
• Integrate external and internal data sets in unified Data Lake and develop query interfaces to address stakeholder needs.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Ph.D. in Bioinformatics, Computational Biology, Systems Biology, Data Science, or Biostatistics.
• 7 years relevant industry and demonstrated leadership experience with immunology, autoimmune disease, and/or oncology background
• Experience mining high-dimensional data with strong statistical and ML background
• Proficiency in R (tidyverse/Shiny/Bioconductor) and Python required.
• Working knowledge of public data resources including GEO, TCGA, ICGC, CCLE, DepMap, cBioPortal, dbGaP, HPA, UK Biobank.
• Strong Linux skills and working knowledge of AWS cloud computing infrastructure.
• Experience working with and developing AI/ML platforms
• High level of emotional intelligence and willingness to work closely and collaboratively with other functional groups internal and external to the company.
• Excellent verbal and written communication skills.

Preferred Qualifications

• Experience working with Rstudio with Rmarkdown reporting, git, Jupyter Notebooks, VScode
• Experience with Python frameworks (eg. PyTorch, Tensorflow/Keras, Scikit-learn, XGBoost)
• Experience with HPC in AWS, Microsoft Fabric, and Nextflow workflow development.
• Experience with database management systems and knowledge graphs.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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