Sr. Scientist, Biologics Research

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

Neurocrine Biosciencesis a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visitneurocrine.com, and follow the company onLinkedIn,XandFacebook. (*in collaboration with AbbVie)

About the Role:

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• Set up cell line development processes and procedures

• Carry out stable CHO transfections on antibody and bispecific programs

• Design and carry out studies to optimize signal peptides and/or ratios for multiple chains

• Expand stable CHO pools for protein expression purposes

• Carry out clonal selection, fed batch evaluation, partnering with team members to evaluate titer, product quality attributes and assess cell line stability

• Maintain appropriate documentation and prepare reports in support of regulatory filings

• Serve as subject matter expert in interactions with CDMOs

• Other duties as assigned

• BS/BA degree and 4+ years of relevant experience OR

• MS/MA degree and 3+ years of relevant experience OR

• PhD or equivalent and some relevant experience in mammalian cell line development may include postdoc experience

• Expert knowledge of molecular cloning, CHO expression vector construction and sequence analysis

• In-depth knowledge of intellectual property landscape of host cell line and expression technology

• Expert knowledge of mammalian protein expression technology and bispecific antibody cell line development

• Extensive experience in creation, maintenance and characterization of clonal CHO cell lines from single cell cloning to RCB including selection of a final clone

• Familiarity with therapeutic protein product quality metrics

• Familiarity with CMC and regulatory requirements

• Strong documentation management skills

• Hands on experience with above and willingness to work in the lab

• Expertise in laboratory operations, including budgeting, capex procurement and IQ/OQ, safety, and status reporting to Senior Management

• Experience with biologics upstream process development a plus

• Demonstrates solid level of understanding project / group goals and methods

• Consistently recognizes anomalous and inconsistent results and interprets experimental outcomes

• Able to explain the process behind the data and implications of the results

• Strong knowledge of one or more scientific disciplines, becoming expert in one discipline

• Strong knowledge of scientific principles, methods and techniques

• Strong knowledge and demonstrated ability working with a variety of laboratory equipment/tools

• Good statistical skills; hands-on experience with DOE study design and statistical analysis

• Ability to work as part of a team; may train lower levels

• Excellent computer skills

• Strong communications, problem-solving, analytical thinking skills

• Detail oriented yet can see broader picture of scientific impact on team

• Ability to meet multiple deadlines, with a high degree of accuracy and efficiency

• Strong project management skills to support and prioritize multiple projects

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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