Postdoctoral, Pulmonary and Critical Care Medicine

Brigham and Women's Hospital
United States, Massachusetts, Boston
75 Francis Street (Show on map)
Apr 09, 2025
To apply, please submit your CV and a letter of interest to Yohannes Tesfaigzi at ytesfaigzi@bwh.harvard.edu. A postdoctoral position is available in Dr. Tesfaigzi Lab in the Pulmonary and Critical Care Medicine, Department of Medicine at the Mass General Brigham, Harvard Medical School. A candidate with a strong background in molecular biology and/or immunology to join our NIH-funded research group to study the innate immune mechanisms of the airway epithelium. In this position, a highly motivated Research Fellow will be engaged in multiple projects related to disease mechanisms of chronic lung diseases, including COPD, asthma, and IPF, with specific attention to identifying the genetic loci and genes that initiate chronic inflammation in the lung. The primary responsibilities of the research fellow will be to conduct experimental research on the role of environmental pollutants in exacerbating cigarette smoke-induced detrimental effects on lung function. These studies will involve using primary and immortalized cells, wild-type and transgenic animal models, and molecular biology and protein biochemistry techniques. The successful candidate will work primarily in the following specific areas: 1) Designing and executing cell and molecular biology studies, 2) handling and improving on animal models of chronic lung diseases, 3) cell lineage tracing, 4) analyzing human samples. 1.Conduct independent research, which requires decision making on methods employed. 2.Perform fundamental scientific tasks and selecting methodologies independently. 3.Set up new cellular assays, analyze complex data sets, and oversee specific phases of research. 4.Assists with the resolution of problems and documents/reports results. 5.Analyze, interpret, and continuously summarize findings as succinct reports. 6.Write and review animal protocols. 7.Collaborate with other scientists and investigators in same or other labs as necessary 8.Providing advice and assistance with experiments and in areas of expertise. 9.Manage lab equipment. 10.Reports results in the form of open literature publications and presentations at scientific meetings. 11.Will be encouraged to write proposals for research funding. 12.Develops scientific network through societies. May participate in special committees as appropriate. 13.Performs other related duties as assigned. Requirements: MD or PhD in Biochemistry or Biological sciences, with experience in biomedical research. Expertise in gene targeting, protein analyses using latest molecular biology and immunology techniques; experience with in vivo CRISPR and single cell RNA sequencing is required. Experience in molecular biology techniques, such as Western blot, immunohistochemistry, immunoprecipitation are required Experience with mouse models of diseases Ready to develop and conduct assays and tests that answer specific scientific questions Knowledge and experience in virology and flow cytometry is a plus Ability to work independently Excellent interpersonal skills are required for working with the study participants Good oral and written communication skills; writes protocols and manuscripts for publications Analytical skills and the ability to resolve technical or research problems and issues and to interpret the acceptability of data results Knowledge of clinical research protocols High degree of computer literacy; skilled with statistical analyses, basic knowledge of analyzing bulk RNA sequencing data Excellent organizational skills and ability to prioritize a variety of tasks The Pulmonary and Critical Care Division is committed to the hiring, advancement and fair treatment of all individuals, and all qualified applicants will receive consideration for employment without regarding to race, color, religion, sex, national origin, sexual orientation, gender identity, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. All applicants and employees are further protected from discrimination based on inquiring about, disclosing or discussing the compensation of other applicants or employees. To apply, please submit your CV and a letter of interest to Yohannes Tesfaigzi at ytesfaigzi@bwh.harvard.edu. Default Add'l Job Description The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.