New

Senior Research Scientist- Integrated Pharmacology

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Oct 08, 2025
Job Description We seek a highly independent, collaborative and innovative scientist to join the Quantitative Cellular Pharmacology team in the Integrated Pharmacology group at Vertex Pharmaceuticals. The ideal candidate will be self-motivated with a strong foundation in cell biology and/or biochemistry and have experience with cell-based/biochemical assays. The successful candidate will be responsible for developing human disease-relevant assays to understand and address the underlying cause of serious life-threatening diseases. Our ideal candidate will have a track record of innovation in the field. The Integrated Pharmacology group supports late-stage drug discovery for all disease areas in the Vertex drug discovery portfolio at the Boston site and the Senior Research Scientist will be a member of multiple discovery project teams. Key Responsibilities: Lead the development of cell-based and/or biochemical assays for small molecule discovery as a key member of discovery project teams Execute cell based and/or biochemical assays supporting medicinal chemistry optimization, characterize our lead molecules in in vitro/in vivo models of human disease and meet deliverables for preclinical development projects Analyze, critically interpret and present data to cross-functional project teams, and recommend courses of action based on datasets and discussions with biologists and chemists Propose and develop innovative approaches to small molecule discovery based on the latest technologies and publications in the field Identify and evaluate new technologies to improve efficiency and processes Strong interpersonal, verbal and written communication skills Be a key member of the Integrated Pharmacology group and serve as a strong representative on interdisciplinary project teams Ensure data integrity and compliance under Vertex policies Knowledge & Skills: Strong understanding of Cell Biology and expertise in cell-based and/or biochemical assay development Target identification/validation, mechanism of action studies and understanding drug candidate pharmacology using innovative approaches and technologies is required Experience with miniaturized assays (384), knowledge of multiplex assay platforms, multi-parametric data analysis and basic command line programming is beneficial Self-motivation, independence, organization, effective communication and presentation skills; adept in solving/troubleshooting complex problems as well as the ability to navigate a fast-paced work environment A desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society Education & Experience: PhD (or equivalent degree) in a relevant discipline (Cell Biology, Molecular Biology, Pharmacology, Biochemistry or related Biological Sciences) and 2-5 years of productive, relevant industry or postdoctoral experience in cell-based and/or biochemical assays to lead discovery, optimization and characterization Masters Degree (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 5+ years of relevant employment experience, or Bachelors Degree (or equivalent degree) in molecular biology, cell biology, biochemistry, or related disciplines and 8+ years of relevant employment experience Pay Range: $118,500 - $177,800 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com