Professional Researcher Position - Bastian Lab

Professional Researcher Position - Bastian Lab

The Bastian Lab at UCSF is seeking a highly motivated, independent, and technically gifted Professional Researcher to lead projects focused on developing and validating rational therapies for uveal melanoma and related malignancies. As a key senior member of our research team, you will drive the preclinical evaluation of novel therapeutic strategies, moving from molecular targets to robust in vivo and in vitro models.

Key Responsibilities

* Experimental Leadership: Design, execute, and troubleshoot complex experiments in cancer biology and pharmacology.

* Drug Development: Lead efforts in drug effectiveness testing, including dose-response studies, synergy analysis, and mechanism-of-action (MoA) studies.

* Advanced Cell Culture: Maintain and manipulate primary tumor cells, PDX-derived cells, and engineered cell lines (including CRISPR/Cas9 or RNAi-based modeling).

* In Vivo Studies: Oversee mouse husbandry and lead xenograft/PDX studies, including drug dosing (IP, oral gavage), tumor monitoring, and tissue collection.

* Lab Operations & Compliance: Serve as a primary point of contact for lab management. This includes overseeing and implementing efficient reagent ordering and inventory systems, as well as maintaining and renewing IACUC (animal) and BUA (biological safety) protocols (or equivalent institutional regulatory filings).

* Communication & Collaboration: Present findings at lab meetings and international conferences; draft manuscripts for publication and contribute data for grant applications.

* Mentorship: Provide technical guidance to post-doctoral fellows, students, and junior staff.

Required Qualifications

* PhD in Cancer Biology, Molecular Biology, Pharmacology, or a related field.

* Technical Excellence: "Excellent hands" at the bench with proven expertise in cell-based assays and molecular biology techniques.

* In Vivo Expertise: Significant experience in mouse models of cancer, including husbandry and therapeutic intervention trials.

* Operational Experience: Proven track record in lab management, including familiarity with institutional procurement systems and regulatory compliance (IACUC/IRB/Biosafety).

* Communication: Exceptional written and verbal communication skills and the ability to work independently.

Applicants must apply online at https://aprecruit.ucsf.edu/JPF05961 with a CV. Candidates must have the required qualifications by time of hire. CV should list pending qualifications. See Table 13B for the salary range for this position. A reasonable estimate for this position is $93,400 - $146,700.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.

* "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer.

* UC Sexual Violence and Sexual Harassment Policy

* UC Anti-Discrimination Policy

* APM - 035: Affirmative Action and Nondiscrimination in Employment