Postdoctoral Fellow - Landstrom Lab

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A Brief Overview
Under the direction/guidance of a mentor (principal investigator), assumes responsibility for a specific, on-going research project. The experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research, and will contribute directly to the overall research goals of the project and the research group.

This role will be expected to participate in project planning, recording and interpretation/evaluation of data, and communication of results. This position will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions and presentations at national meetings. This role also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

Title: Postdoctoral fellow in cardiovascular genetics specializing in big data and AI-modeling - CHOP/UPenn, Philadelphia, USA. Description: A postdoctoral fellow position is available in the laboratory of Dr. Anderw Landstrom at the Cardiovascular Institute at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania (UPenn). The Landstrom laboratory uses a range of molecular and cellular biology, human genetcs, and translational clinical phenotype platforms to study the underpinnings of cardiomyopathies and cardiac channelopathies. The candidate will work closely with Dr. Landstrom and the research team to develop AI-based models for predicting disease risk, and disease progression, based on genome sequencing and large clinical databases. The candidate will have the opportunity to apply this work across a range of heritable cardiovascular diseases, linking basic science inquiry with clinically impactful outcomes. Candidates must have a PhD (or equivalent) and significant experience in genomics, informatics, and artificial intelligence. Candidates would ideally have experience in human genetics, cardiovascular disease, and clinical disease phenotype data. Recent publications from the Landstrom Lab in this arena are below: Gurumoorthi M, Dabbagh GS, Wolfe R, Hesse K, Shah R, Kurzlechner L, Yadav K, Balint B, Asatryan B, Sheikh F, Chahal CAA, Landstrom AP. Disease penetrance and phenotypic spectrum of desmoplakin variant carriers in the population. Heart Rhythm. 2025. Oct 21:S1547-5271(25)03024-3. PMID: 41130550 Moya-Mendez ME, Bidzimou MT, Muralidharan P, Zhang Z, Ezekian JE, Perelli RM, Parker LE, Prange L, Boggs A, Kim JJ, Howard TS, Word TA, Wehrens XHT, Valenzuela GR, Caraballo R, Garone G, Vigevano F, Weckhuysen S, Millevert C, Troncoso M, Matamala M, Balestrini S, Sisodiya SM, Poole J, Zucca C, Panagiotakaki E, Papadopoulou MT, Tchaicha S, Sauquet J, Zawadzka M, Mazurkiewicz-Bedziska M, Fons C, Anticona J, De Grandis E, Cordani R, Pisciotta L, Groppa S, Paryjas S, Ragona F, Mangia E, Granata T, Pavlicek M, Ess K, Simmons CQ, George AL, Vavassori R, Mikati MA, Landstrom AP. ATP1A3 Variants, Variably Penetrant Short QT Intervals, and Lethal Ventricular Arrhythmias. JAMA Peds. 2025 May 1;179(5):529-539. PMID: 40029639 Perelli RM, Dewars ER, Cope H, Behura AS, Ponek AQ, Sala AM, Zhang Z, Muralidharan P, Moya-Mendez ME, Berkman A, Monaco GG, Sullivan MC, Ezekian JE, Yang Q, Sun B, Kurzlechner LM, Asokan T, Breglio AM, Campbell MJ, Spector ZZ, Rehder CW, Undiagnosed Diseases Network, Tang PC, James CA, Calkins H, Shashi V, Landstrom AP. TAX1BP3 causes TRPV4-mediated autosomal recessive arrhythmogenic cardiomyopathy. Circ Res. 2025. Mar;136(7):667-684. PMID: 39963794 Full publication list: https://www.ncbi.nlm.nih.gov/myncbi/andrew.landstrom.1/bibliography/public/ CHOP is an equal opportunity employer. Postdoctoral fellows are provided with comprehensive benefits package including eligible health insurance and retirement plan (http://www.research.chop.edu/careers/working-research/benefitsinformation). CHOP and UPenn offer outstanding research and training environment. The lab is fully committed to the success and career development of every team member. Previous team members are currently working in both academic (universities, hospitals, etc.) and industry (pharmaceutical, biotech, etc.) positions. Contact: Applicant should submit a cover letter detailing her/his research background and interest, why she/he is interested in joining the lab, a current CV.

What you will do

• Conduct independent scholarly research and develop new methods and protocols
• Participate in project planning, recording and evaluation of data
• Acquire technical, lab management and grant writing skills
• Participate in seminars, lectures, poster sessions and presentation at national meetings
• Supervise junior lab members
• Assist with other research projects

Education Qualifications

• Doctorate Required

Skills and Abilities

• Ability to wear a respirator device

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SALARY RANGE:

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

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