Principal Scientist, Cell Line Engineering

A career in Boston - main video - YouTube

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

The Mammalian Expression Technologies Center of Excellence (MET CoE) at GSK Vaccines is responsible for the generation of CHO-based production cell lines for the expression of innovative recombinant protein vaccines.

The MET CoE is looking for a motivated scientist to support next-generation cell line engineering initiatives. Located in Cambridge, MA, the position will play a significant role in shaping current and next generation GSK's leading vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health. This role provides the opportunity to integrate a diverse group of top talented experts in vaccines' industry, lead key activities and further grow and progress in your career. These activities will include:

• Design and develop omics-based screening strategies for discovery of novel gene targets in CHO cells.
• Perform advanced NGS data analytics to elucidate key biological targets for next-generation CHO host evolution.
• Stay up to date with the latest quality and regulatory guidance to support project documentation and accelerated CMC timelines.

The successful applicant may spend 3-6 months within the first year of hire in Rockville, MD to support and guarantee a smooth transition of methods and know-how to the new laboratories in Cambridge, MA.

Basic Qualifications:

We are looking for professionals with these required skills to help us achieve our goals:

• PhD with 2+ years' industry experience in molecular biology, computational biology, genetics, or another relevant field.
• Two or more years of experience with NGS techniques (wet and dry lab) and associated methodologies, including analyses of large datasets.
• Two or more years of experience with the implementation of genome-scale modelling approaches to establish biological and mechanistic networks.

Preferred Qualifications:

The following skills are a plus for this role:

• Hands-on experience with mammalian cell culture, including clonal derivation and transfection.
• Experience with genome-editing tools for mammalian cell engineering.
• Deep understanding in CMC drug substance space as it relates to cell line development.

#Vx-Cam

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.