Senior Associate Scientist, DMPK

The DMPK group at Alnylam is seeking a highly motivated Sr. Associate Scientist to join our DMPK team to help advance novel RNAi therapeutic programs from discovery to clinic. This individual will contribute to optimizing and implementing DMPK relevant assays to support early through late-stage drug development programs using in-vitro techniques (cell free and cell culture systems) and Bio-analytical techniques like MSD, LCMS-MS etc. They will assist in ADME drug characterization, execute assays and sample analysis to evaluate the pharmacokinetic (PK) and Pharmacodynamic (PD) response to advance RNAi therapeutic development. The ideal candidate will have background in pharmaceutical, biological, or biochemical sciences, hands-on-bench skills in cell free systems and cell culture techniques, and attention to detail. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Assist in assay optimization and qualification of in vitro DMPK assays across technologies in cell free or cell culture systems
• Assist in assay optimization and qualification of safety pharmacology experiments to assess the safety of RNAi therapeutics for early and late-stage development
• Perform non-GLP sample analysis to support all Alnylam's RNAi therapeutics development from early to late stage
• Use scientific literature and scientific knowledge to improve experimental design and inform project direction.
• Maintain appropriate procedures and controls to ensure consistent assay performance and reproducible data
• Maintain high quality documentation, perform data analysis and monitor performance of Quality Controls.
• Learn in-depth knowledge about the technologies and platforms used to generate results to help troubleshoot, address queries, and present data to diverse groups within Research and Development.
• Collaborate cross-functionally and represent DMPK group
• Research and implement new technologies to improve assay performance, quality, and efficiency.

Qualifications

• A Master's degree (3+ years of pharmacokinetic assays bench-work experience) or Bachelor's degree (5+ years of pharmacokinetic bench-work experience) in biology, pharmaceutical sciences, biochemistry, chemistry, or relevant field.
• Hands-on molecular bench-work experience (MSD, LCMS/MS, ELISA)
• Must have experience with Excel, Word, and PowerPoint.
• Experience with other analytical software is a plus (e.g. Phoenix, GraphPad Prism, Discovery Workbench).
• Detail-oriented with the ability to thrive in a team environment and be comfortable working on multiple projects.
• Meticulous and diligent at record keeping and organizing experiment files to be readily accessible to the team
• Possesses excellent interpersonal, verbal and written communication skills to enable collaboration with cross-functional teams
  

About Alnylam:Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by "interfering" with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture:Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we've been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine's Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK - among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.