Scientific Director, Global Medical Affairs - ATTR

Overview

The Scientific Director, Global Medical Affairs - ATTR serves as a global scientific subject matter expert supporting the ATTR franchise, with a primary focus on scientific content generation and written scientific outputs. This role reports to the VP, Medical Affairs, TTR and works in close partnership with Global Medical Leads across ATTR assets (e.g., Vutrisiran, Nucresiran).

The role will contribute deep scientific expertise to publications strategy, investigatorinitiated studies (IIS), research collaborations, posthoc analyses, Phase 4 activities, and business development due diligence, with a strong emphasis on handson writing, protocol development, and scientific review.

The role supports increasing demand for highquality scientific content and evidence generation across the ATTR franchise and will function as a core internal SME supporting crossfunctional teams.

Key Responsibilities

Scientific Content Development & Publications

• Serve as a scientific SME contributing to global publication strategy, planning, and execution.
• Draft, review, and critically edit scientific manuscripts, abstracts, posters, slide decks, and congress materials.
• Provide scientific leadership on data interpretation and scientific storytelling, ensuring accuracy, clarity, and alignment with the overall evidence strategy.

Evidence Generation

• Support development, review, and execution of the integrated evidence generation plan across the ATTR franchise.
• Support IIS, Research Collaboration, Phase 4, post-marketing, post-hoc analyses, real-world evidence activities, including scientific review, study and analyses design, feasibility assessment, data interpretation, and ongoing oversight.
• Lead protocol development and review across evidence generation activities, with a focus on scientific rigor and relevance.

Cross Functional Scientific Partnership

• Collaborate closely with Global Medical Leads, Publications and Scientific Communications, Clinical Research, Regulatory, HEOR, and Commercial partners to ensure alignment and scientific integrity.
• Support crossfunctional deep dives led by Value Evidence Strategy teams, synthesizing scientific and clinical data into clear, written outputs.
• Provide scientific input into business development and licensing (BD&L) due diligence, including literature reviews, data gap assessments, and scientific risk evaluation.
• Contribute to internal briefing documents, scientific summaries, and strategic analyses to inform senior leadership decisionmaking.
• Serve as a trusted internal scientific reviewer for medical materials, protocols, and externalfacing scientific content.
• Ensure all activities adhere to medical governance, compliance, and ethical standards.

Qualifications

• PharmD, PhD or MD
• 3-5+ years of relevant experience within the pharmaceutical or biotechnology industry.
• Experience in cardiovascular, renal, metabolic, or ATTR disease areas strongly preferred.
• Demonstrated primary authorship and substantial contribution to peerreviewed publications.
• Strong experience in medical, scientific, and grant writing (e.g., research proposals, manuscripts) and reviewing or developing clinical or postmarketing study protocols.
• Prior exposure to BD due diligence or structured scientific evaluations strongly preferred.
• Deep interest in and aptitude for written scientific work; this role emphasizes writing over presenting.
• Ability to critically analyze data and translate complex science into clear written narratives.

U.S. Pay Range

$238,800.00 - $323,000.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.